The San Francisco 49ers (1-1) will play NFC West rivals, the Los Angeles Rams (0-2), on Sunday, September 22, 2024 at SoFi Stadium. The 49ers are listed as favorites in this one, with the spread sitting at 6.5 points. An over/under of 43.5 points has been set for the outing.
Against the Arizona Cardinals in their most recent game, the Rams lost 41-10.
The Rams’ Matthew Stafford was 19-for-27 for 216 yards versus the Cardinals, with no TDs and no INTs.
In their last game, the 49ers lost against the Minnesota Vikings, 23-17.
Rams vs 49ers betting information
NFL odds courtesy of BetMGM Sportsbook. Odds updated Saturday at 4:35 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread Favorite: San Francisco (-6.5)
- Moneyline: San Francisco (-295), Los Angeles (+237)
- Total: 43.5 points
Rams betting insights
- Los Angeles was 5-3 overall, and 5-3 against the spread, at home last season.
- The Rams are winless against the spread this season (0-2-0).
- Los Angeles was unbeaten ATS (1-0) as 6.5-point underdogs or greater at home last year.
- In eight games at home last season, Los Angeles went over the total three times.
- Games involving the Rams have hit the over once this season.
Rams leaders
- Stafford: 533 PASS YDS / 266.5 YPG / 69.7% / 1 TD / 1 INT
- Kyren Williams: 30 CAR / 75 YDS / 37.5 YPG / 2 TD / 7 REC / 31 YDS / 15.5 YPG / 0 TD
- Blake Corum: 8 CAR / 28 YDS / 14.0 YPG / 0 TD
- Cooper Kupp: 18 REC / 147 YDS / 73.5 YPG / 1 TD
- Tyler Johnson: 7 REC / 99 YDS / 49.5 YPG / 0 TD
- Demarcus Robinson: 6 REC / 92 YDS / 46.0 YPG / 0 TD
Rams vs 49ers game info
- Date: Sunday, September 22, 2024
- Time: 4:25 p.m. ET
- City: Inglewood, California
- Venue: SoFi Stadium
- TV Channel: FOX
- Live Stream: Fubo (Watch 49ers vs Rams on Fubo)
Watch the Los Angeles Rams all season on Fubo!