The Chargers secured a win in Week 1, but their defense suffered a notable loss along the way. Linebacker Denzel Perryman departed early in the contest, and he was in a walking boot after the game. 
Testing has taken place, and Ian Rapoport of NFL Network reports a high ankle sprain has been diagnosed. As a result, missed time is in store. High ankle sprains tend to carry a recovery timeline of multiple weeks, so a move to injured reserve could be in store.
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An IR stint would require at least a four-game absence, so it will be interesting to see how the Chargers proceed in this case. Head coach Jim Harbaugh said on Monday (via ESPN’s Kris Rhim) no decision regarding IR has been made yet. Perryman played eight snaps on Friday before suffering the injury. His departure represented a blow to the Chargers’ defense, although the unit nevertheless enjoyed a solid outing in the 27-21 win over the Chiefs.
Perryman has served as a full-time starter for much of his career, including his second Chargers stint. The 32-year-old returned to Los Angeles last offseason on a one-year pact. He was limited to 11 games, but when on the field the former second-rounder was a key figure defensively. Perryman took another one-year deal in March to stay with the Bolts, and by late May he was fully recovered from the elbow injury he suffered in the wild-card round.
A fully healthy season would have been critical for team and player, but that will not be the case in 2025. Perryman is set to spend time on the shelf, something which will leave Los Angeles thin at the second level. Junior Colson was placed on season-ending injured reserve during roster cuts due to a shoulder injury. 2023 third-rounder Daiyan Henley and sixth-year veteran Troy Dye handled much of the linebacker work on Friday, and that will likely continue with Perryman sidelined.
The former Pro Bowler’s 2026 market value will take a hit with further missed time. In the event the Chargers do not move him to injured reserve, however, Perryman will be eligible to return within the next four weeks.