The Chargers had their final practice on Friday ahead of the Week 14 game against the Broncos.
Offensive lineman Zack Bailey (back), cornerback Deane Leonard (ankle/heel) and wide receiver Joshua Palmer (knee) have been ruled out.
Brandon Staley said the plan is for CB Michael Davis to start in place of Leonard.
Linebacker Amen Ogbongbemiga (hamstring) and defensive tackle Otito Ogbonnia (knee) are questionable.
As for the Broncos, running back Samaje Perine is questionable with a knee injury.